ValerianeTher. class.antianxiety agentssedative/hypnotics
May increase concentrations of the inhibitory CNS transmitter GABA.
Improvement in sleep quality.
Metabolism and Excretion: Unknown.
|PO||3060 min||2 hr||unknown|
Pregnancy and lactation.
Use Cautiously in:
Alcohol use (may have additive sedative effects);
Surgery (discontinue use 2 weeks prior to elective procedures).
Adverse Reactions/Side Effects
CNS: drowsiness, headache.
GI: dry mouth.
Misc: Benzodiazepine-like withdrawal symptoms with discontinuation after long-term use.
*CAPITALS indicates life-threatening.
*italic indicates most frequent.
Additive CNS depression with alcohol , antihistamines , anesthetic agents sedative hypnotics and other CNS depressants .
Alcohol-containing preparations may interact with disulfiram and metronidazole .Natural Products-Natural Products
Additive sedative effects can occur when used with herbal supplements with sedative properties such as kava , l-tryptophan
, melatonin , SAMe
, and St. John's wort .
PO (Adults): Tea1 cup tea 15 times daily. Tea is made by steeping 23 g root in 150 mL boiling water for 510 min then straining. Tincture13 mL 15 times daily. Extract400900 mg up to 2 hours before bedtime or 300450 mg divided tid..
Assess degree of anxiety and level of sedation prior to and periodically throughout therapy.
Assess sleep patterns.
Assess response in the elderly population where drowsiness and loss of balance may pose a significant risk for injury.
Potential Nursing Diagnoses
Risk for injury (Side Effects)
Take one to two hours before bedtime if used for nighttime hypnotic.
Administer orally three to five times daily to control anxiety.
Encourage patients to avoid stimulants such as caffeine and to provide an environment that promotes restful sleep.
May cause drowsiness. Caution patient to avoid driving or other activities requiring alertness until response to drug is known.
Caution patient to avoid use of alcohol and other medications or herbals that have a sedative effect; may increase drowsiness.
Advise patients to discontinue 2 weeks prior to elective surgical procedures.
Inform patients not to take this herbal supplement if pregnant or breast-feeding.
Notify patients that dependence with withdrawal symptoms may develop with prolonged use.
Decreased anxiety level.
Improvement in sleep with a feeling of restfulness without drowsiness upon awakening.