Contraindication/Precautions

Contraindicated in:

• Hypersensitivity

• Hepatic impairment

• Known/suspected urea cycle disorders (may result in fatal hyperammonemic encephalopathy)

• Bleeding disorders

• History of liver disease

• Organic brain disease

• Bone marrow depression

• Renal impairment

• Geri: risk of adverse effects

• OB: Use during pregnancy is linked to congenital anomalies, neural tube defects, clotting abnormalities, and hepatic dysfunction in the neonate. Use with extreme caution. Lactation: Pass into breast milk. Consider discontinuing nursing when valproates are administered to the nursing mother

• Pedi: Children, especially <2 yr (at risk for potentially fatal hepatotoxicity)

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