Interactions

Drug-Drug

• risk of bleeding with warfarin

• Blood levels and toxicity may be by aspirin, carbamazepine, chlorpromazine, cimetidine, erythromycin, or felbamate

• CNS depression with other CNS depressants, including alcohol, antihistamines, antidepressants, opioid analgesics, MAO inhibitors, and sedative/hypnotics

• MAO inhibitors and other antidepressants may seizure threshold and effectiveness of valproate

• Carbamazepine, meropenem, phenobarbital, phenytoin, or rifampin may valproate blood levels

• Valproate may toxicity of carbamazepine, diazepam, amitriptyline, nortriptyline, ethosuximide, lamotrigine, phenobarbital, phenytoin, topiramate, or zidovudine

• Concurrent use with topiramate may risk of hypothermia

• Ertapenem, imipenem, or meropenem may valproate blood levels

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