Interactions

Drug-Drug

• ↑ risk of bleeding with warfarin

• Blood levels and toxicity may be ↑ by aspirin , carbamazepine , chlorpromazine , cimetidine , erythromycin , or felbamate

• ↑ CNS depression with other CNS depressants , including alcohol , antihistamines , antidepressants , opioid analgesics , MAO inhibitors , and sedative/hypnotics

• MAO inhibitors and other antidepressants may ↓ seizure threshold and ↓ effectiveness of valproate

• Carbamazepine , meropenem , phenobarbital , phenytoin , or rifampin may ↓ valproate blood levels

• Valproate may ↑ toxicity of carbamazepine , diazepam , amitriptyline, nortriptyline , ethosuximide , lamotrigine , phenobarbital , phenytoin , topiramate , or zidovudine

• Concurrent use with topiramate may ↑ risk of hypothermia

• Ertapenem , imipenem , or meropenem may ↓ valproate blood levels

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