Implementation

Do not confuse Pitressin (vasopressin) with Pitocin (oxytocin)

» Aqueous vasopressin injection may be administered subcut or IM for diabetes insipidus

» Administer 1–2 glasses of water at the time of administration to minimize side effects (blanching of skin, abdominal cramps, nausea)

• Direct IV:
Diluent: Administer undiluted.
Concentration: 20 units/ml

• Rate:
Administer over 1–2 sec during pulseless VT/VF, asystole, or PEA

• Continuous Infusion:
Diluent: Dilute 100 units of vasopressin in 250 ml of 0.9% NaCl or D5W.
Concentration: 0.4 units/ml

• Rate:
See Route/Dosage section

• Y-Site Compatibility:

» amiodarone

» argatroban

» ciprofloxacin

» diltiazem

» dobutamine

» dopamine

» drotrecogin

» epinephrine

» fluconazole

» gentamicin

» heparin

» imipenem/cilastatin

» insulin

» lidocaine

» linezolid

» meropenem

» metronidazole

» milrinone

» nitroglycerin

» norepinephrine

» pantoprazole

» phenylephrine

» procainamide

» sodium bicarbonate

• Y-Site Incompatibility:

» diazepam

» phenytoin

» trimethoprim/sulfamethoxazole

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