Assessment

• Monitor BP, HR, and ECG periodically throughout therapy and continuously throughout cardiopulmonary resuscitation

• Monitor urine osmolality and urine volume frequently to determine effects of medication. Assess patient for symptoms of dehydration (excessive thirst, dry skin and mucous membranes, tachycardia, poor skin turgor). Weigh patient daily, monitor intake and output, and assess for edema

• Monitor urine specific gravity throughout therapy

» Monitor serum electrolyte concentrations periodically during therapy

• Signs and symptoms of water intoxication include confusion, drowsiness, headache, weight gain, difficulty urinating, seizures, and coma

» Treatment of overdose includes water restriction and temporary discontinuation of vasopressin until polyuria occurs. If symptoms are severe, administration of mannitol, hypertonic dextrose, urea, and/or furosemide may be used

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