Observe patient for at least 30 min following injection for immediate-onset systemic allergic reactions (urticaria, pruritus, hypotension, syncope). Treat symptomatically; if hypotension or syncope occur measures such as leg elevation, oxygen, IV fluids, antihistamines, corticosteroids, and epinephrine should be used. Risk of reaction increases with duration of treatment.
Lab Test Considerations:
Measure serum total testosterone concentrations just prior to administration on Day 29 and every 8 wk thereafter. Overall effectiveness may decrease with increased duration of therapy.
- May cause ↑ serum AST and ALT levels. Monitor serum transaminase levels prior to and periodically during therapy.
- Monitor serum PSA levels periodically during therapy.
- May cause slight ↓ in hemoglobin.
- May cause ↑ in serum triglycerides.
- May cause ↓ in bone mineral density.