|
alitretinoin Classification |
| ROUTE | ONSET | PEAK | DURATION |
| topical | 2 wk | 4–14 wk | unknown |
Assess skin lesions before and periodically throughout therapy to determine effectiveness.Assess patient for dermal toxicities throughout therapy. Dermal toxicity may begin with erythema, which may increase, and edema may develop with continued application. Severe toxicity (as evidenced by erythema, edema, or vesiculation) may limit treatment. If toxicity occurs, decrease frequency of application. If extreme irritation occurs, discontinue for a few days until symptoms subside.Topical: Apply sufficient gel to cover lesion with a generous coating twice daily initially. May increase to 3–4 times daily if tolerated. Allow gel to dry for 3–5 minutes before covering with clothing. Avoid application of gel to healthy skin surrounding lesions or on or near mucosal surfaces; skin may become irritated. Do not cover with occlusive dressing.Instruct patient in correct method for application of gel. Emphasize the importance of continuing treatment, even if results are not visible. Prolonged therapy may be required.Advise patient to notify health care professional if signs of dermal toxicity occur.Caution patient to minimize exposure of treated areas to sunlight or sunlamps to prevent photosensitivity reactions.Advise patient to avoid use of products, such as insect repellents, which contain DEET during treatment. Alitretinoin may increase DEET toxicity.Decrease in cutaneous lesions of KS. Effects may be seen as early as 2 weeks, but most patients require 4–8 weeks for response. Some patients require more than 14 weeks for significant improvement. Gel application should be continued as long as patient is deriving benefit from it.