Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.
L-tryptophan is an essential amino acid that is converted by the body to 5–hydroxytryptophan (5–HTP) and then to serotonin. Both L-tryptophan and 5–HTP cross the blood-brain barrier and have sedative effects. Depletion of endogenous tryptophan can cause a relapse in depression symptoms.
Metabolism and Excretion: Unknown
Use Cautiously in:
CNS: ataxia, headache, drowsiness, lightheadedness
EENT: visual blurring
GI: heartburn, abdominal pain, dry mouth, nausea
Hemat: eosinophilia-myalgia syndrome
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Natural Drug Interaction
PO (Adults): Insomnia– 1 gram 20 minutes before bedtime; Depression– 300 mg/day; Prementrual syndrome– 6 grams/day; Smoking cessation– 50 mg/kg/day.
Tablets: 500 mg
Improvement in insomnia and premenstrual disorder.
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