Endo: adrenal suppression (↑ risk with use over larger surface areas, use of occlusive dressings, use on altered skin barriers, hepatic impairment, or long-term therapy)
* CAPITALS indicate life-threatening. Underline indicate most frequent.
↑ risk of photosensitivity reactions with other photosensitizing drugs including fluoroquinolones, phenothiazines, sulfonamides, tetracyclines, and thiazides.
Topical (Adults): Apply to affected area(s) once daily.
Lotion: halobetasol 0.01%/tazarotene 0.045%
Assess skin lesions before and periodically during therapy.
Assess for signs and symptoms of skin irritation (redness, peeling, discomfort) during therapy. If irritation occurs, reduce frequency of application or temporarily stop therapy; resume once irritation subsides.
Lab Test Considerations:
Obtain a negative pregnancy test within 2 wks of starting therapy.
Total dose should not exceed 50 g per wk due to potential for suppression the hypothalamic-pituitary-adrenal (HPA) axis. Avoid occlusive dressings unless directed by health care professional. Do not apply to face, groin, or axilla.
Topical Apply thin layer Duobrii lotion once daily to dry skin to cover only affected areas and rub in gently.
Instruct patient to apply Duobrii lotion as directed and to limit dose to no more than 50 g/wk. Avoid bandaging, wrapping or occluding treatment areas, unless directed by health care professional. Advise patients to avoid use on face, groin, or axilla. Lotion is only for external use; not for oral, ophthalmic, or intravaginal use. Advise patient to read Patient Information before starting therapy and with each Rx refill in case of changes.
Caution patient to use only as directed. Avoid using cosmetics, bandages, dressings, or other skin products over the treated area unless directed by health care professional.
Advise patient to notify health care professional if skin irritation, blurred vision or visual changes occur.
Caution patient to wear protective clothing, use sunscreen, and avoid exposure of treated areas natural or artificial sunlight, tanning beds, and sunlamps to prevent photosensitivity reactions.
Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
Rep: May be teratogenic. Advise females of reproductive potential to use effective contraception during therapy. Advise patient to notify health care professional immediately if pregnancy is suspected and or if breastfeeding. Advise females who are breastfeeding to avoid application directly to nipple and areola and to avoid direct infant exposure.
Clearing of plaques. Discontinue treatment when control is achieved.
halobetasol/tazarotene is a sample topic from the Davis's Drug Guide.
Davis’s Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. Includes App for iPhone, iPad, and Android smartphone + tablet. Handbook covers dosage, side effects, interactions, uses. Davis Drug Guide PDF. Complete Product Information.