**Off Market Drug**
This medication is no longer available in the United States. Information provided here is for reference purposes only.
Pronunciation:
mi-kon-a-zole
Trade Name(s)
Ther. Class.
antifungals (oral, nonabsorbed)
Treatment of oropharyngeal candidiasis.
Affects the permeability of the fungal cell wall, allowing leakage of cellular contents.
Therapeutic Effect(s):
Decrease in symptoms of oropharyngeal candidiasis.
Absorption: Minimal systemic absorption.
Distribution: Inhibitory concentrations remain in saliva for up to 7 hr after buccal application of tablet.
Metabolism and Excretion: .
Half-life: .
TIME/ACTION PROFILE
ROUTE | ONSET | PEAK | DURATION |
---|---|---|---|
PO | unknown | unknown | up to 15 hr |
Contraindicated in:
Use Cautiously in:
CNS: headache
GI: abnormal mouth sensations, diarrhea, dry mouth, dysgeusia, ↑ liver function tests, nausea, vomiting
Derm: pruritis
Misc: ANAPHYLAXIS
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Drug-Drug
May ↓ metabolism and ↑ risk of toxicity from CYP3A4 substrates, including cyclosporine, HMG-CoA reductase inhibitors, some benzodiazepines ( alprazolam, midazolam, triazolam ), calcium channel blockers, colchicine, fentanyl, sulfonylureas ( glipizide, glyburide ), phenytoin, tacrolimus, and warfarin.
PO (Adults): One buccal tablet once daily for 14 days.
Buccal tablet: 50 mg
Lab Test Considerations:
Monitor hepatic function prior to and periodically during therapy. May cause ↑AST.
Instruct patient to take miconazole as directed. Describe application and what to do if tablet falls off or is swallowed.
Decrease in symptoms of oropharyngeal candidiasis.
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