Prevention of hereditary angioedema (HAE) attacks.
Acts as a selective, reversible inhibitor of kallikrein, thereby inhibiting its action in initiating bradykinin production, part of the cascade of events in HAE.
Reduction in number of HAE attacks.
Absorption: Well absorbed following subcutaneous administration.
Distribution: Well distributed to tissues.
Metabolism and Excretion: Unknown.
Half-life: 14–15 days.
TIME/ACTION PROFILE (plasma concentrations)
- OB: Pregnancy (may cause fetal harm, especially during 3rd trimester);
Use Cautiously in:
- Lactation: Use while breastfeeding only if potential maternal benefit justifies potential risk to infant;
- Pedi: Children <12 yr (safety and effectiveness not established).
Adverse Reactions/Side Effects
GI: diarrhea, ↑ liver enzymes
Local: injection site reactions
Neuro: headache, dizziness
Resp: upper respiratory infection
Misc: HYPERSENSITIVITY REACTIONS (including anaphylaxis)
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Subcut (Adults and Children ≥12 yr): 300 mg every 2 wk. If patient has been free of attacks for >6 mo, can adjust regimen to 300 mg every 4 wk.
Solution for injection: 150 mg/mL
- Assess for signs (facial, laryngeal, or abdominal swelling, dyspnea, pain, nausea, vomiting, cramps, diarrhea) and frequency of HAE.
- Monitor for signs and symptoms of severe hypersensitivity reactions (hives, urticaria, chest tightness, wheezing, hypotension, anaphylaxis) during or after injection.
- Deficient knowledge, related to medication regimen (Patient/Family/Teaching)
- Subcut Remove vial from refrigerator 15 min before injecting to allow to warm to room temperature. Does not require reconstitution or dilution. Solution is clear to slightly opalescent, colorless to slightly yellow; do not administer solutions that are cloudy, discolored, or contain particulate matter. Do not shake vial. Withdraw dose from vial using an 18-gauge needle. Change to 27-gauge, 1/2 inch needle. Inject slowly into abdomen, thigh, or upper arm over 10–60 sec. Inject within 2 hr of preparing dosing syringe; may be refrigerated and used within 8 hr. Discard unused portion of vial.
- Instruct patient in correct technique for injection, storage, and place to discard syringes and needles.
- Advise patient to notify health care professional immediately if signs and symptoms of hypersensitivity reaction occur.
- Advise patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Decrease in frequency, intensity, and duration of symptoms of HAE.
To view other topics, please log in or purchase a subscription.
Davis’s Drug Guide for Nurses App + Web from F.A. Davis and Unbound Medicine covers 5000+ trade name and generic drugs. Includes App for iPhone, iPad, and Android smartphone + tablet. Handbook covers dosage, side effects, interactions, uses. Davis Drug Guide PDF. Complete Product Information.