Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.
- 2-amino-2-deoxyglucose sulfate
- Temporomandibular joint (TMJ) arthritis.
May stop or slow osteoarthritis progression by stimulating cartilage and synovial tissue metabolism.
Decreased pain and improved joint function.
Absorption: 0.9% absorbed
Metabolism and Excretion: 74% eliminated via first-pass metabolism
- Shellfish allergy (glucosamine is often derived from marine exoskeletons)
- Pregnancy and lactation.
Use Cautiously in:
- Diabetes (may worsen glycemic control)
- Asthma (may exacerbate symptoms)
- Surgery (may affect blood glucose levels, discontinue glucosamine 2 wk before elective procedures)
Adverse Reactions/Side Effects
GI: nausea, heartburn, diarrhea, constipation
Derm: skin reactions
Neuro: headache, drowsiness
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Natural Drug Interaction
- May antagonize the effects of antidiabetics.
- May induce resistance to some chemotherapy drugs such as etoposide, teniposide, and doxorubicin.
- May increase anticoagulant effects of warfarin.
PO (Adults): 500 mg three times daily.
Topical (Adults): use cream as needed for up to 8 wk.
Tablets: 500 mgOTC
Capsules: 500 mgOTC
Topical cream: 30 mg/g in combination with other ingredientsOTC
- Assess for shellfish allergy prior to initiating therapy.
- Monitor pain (type, location, and intensity) and range of motion periodically during therapy.
- Assess bowel function periodically during therapy. Constipation may be reduced by increased fluid intake and bulk in diet; bulk laxatives may be added if necessary.
Lab Test Considerations:
Monitor serum glucose levels periodically during therapy for patients with diabetes.
- Chronic pain (Indications)
- Impaired physical mobility (Indications)
- Administer prior to meals.
- Instruct patients that effects of this drug come from stimulating cartilage and synovial tissue metabolism and that the supplement must be taken on a regular basis to achieve benefit. Do not use as an intermittent pain medication.
- Caution patients with a shellfish allergy that this herbal supplement should not be used.
- Advise patient to notify health care professional if gastric discomfort develops and persists.
- Advise diabetic patients to monitor glucose values closely during initial therapy.
Improvement in pain and range of motion.
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